De-Escalating Anti-Pseudomonal β-Lactams

نویسندگان

  • J Catteeuw
  • L De Bus
  • W Denys
  • B Gadeyne
  • JJ De Waele
  • J Decruyenaere
  • PO Depuydt
چکیده

Methods We retrospectively included all ICU episodes in Ghent University Hospital during 2013 and 2014 with prescription of meropenem, piperacillin-tazobactam or ceftazidime for at least 48 hours, stratifying between ICU episodes of < and ≥4 days; for outcome analysis, only the first ≥4 days episode per patient was included. Deescalation was defined as a change from meropenem to a non-carbapenem antibiotic other than colistin or aminoglycosides or a change from ceftazidime or piperacillin-tazobactam to a non anti-pseudomonal antibiotic. Organ failure improvement was defined as a decrease of the SOFA score between day 3 and day 1 of the infection for which the beta-lactam was prescribed. Antibiotics were considered appropriate if they covered all etiologic pathogens of the infection. Multidrug-resistant (MDR) pathogens were defined according to Magiorakos et al. (1). Acquisition of MDR pathogens was defined as the identification of MDR pathogens more than 2 days after the start of the antibiotic under study and not present before this date.

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عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2015